Research Hub

The Hoffman Effect

Cancer cells in many tumor types show an unusually high dependence on external (dietary) methionine — a phenomenon researched by Prof. Robert M. Hoffman (UCSD / AntiCancer Inc.) and sometimes called "methionine addiction." Restricting dietary methionine has been studied preclinically and in a growing number of published clinical case reports as a way to selectively stress cancer cells, sometimes alongside chemotherapy.

This is an early-stage, actively-researched area — mostly preclinical studies plus individual case reports, not large randomized controlled trials. It is not part of standard oncology treatment guidelines, and no methionine-restricting drug is FDA-approved for cancer treatment. Nothing on this page is medical advice — it exists to make primary sources and calculation tools easy to find. Talk to a doctor or registered dietitian before making dietary changes, especially during cancer treatment.

Research Library

Primary-source papers on methionine restriction, methioninase, and related pancreatic/breast-cancer research. Every citation below was transcribed directly from the paper's own title page — click "DOI / Source" to verify independently. Click "Read Aloud" to open the paper in the Reading Room with full text-to-speech controls.

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Have a paper you think belongs here? See Contact & Submissions below.

Methionine Calculator & Barcode Scanner

Live USDA FoodData Central lookup — search by name, scan a package barcode, or use voice input. This tool only calculates and displays numbers; it does not set or suggest a daily limit. Every value it shows is fetched live from USDA at the moment you look it up, and it always tells you when a number is lab-measured versus a disclosed estimate.

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Open the Calculator & Scanner

USDA food search, barcode scan, voice input, shopping list, saved recipes, and a full nutrient profile view.

Recipes

Meal ideas with real photographs and ingredients that link straight to their USDA FoodData Central entry — no invented nutrition numbers, ever. This section is actively being built out; the starter recipes below already live in the calculator (linked above) and pull their nutrition live from USDA rather than storing any number here.

📷 Photographed recipe cards are in progress. In the meantime, starter recipes with live USDA-sourced nutrition are available inside the Calculator — open it and click "📖 Recipes."

Contact & Research Submissions

GitHub Pages doesn't support comments, so if you have a research paper, correction, or question, reach out directly.

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Submit a Research Paper

Send a DOI, PDF, or link — include the title, authors, and publication so it can be catalogued accurately.

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General Contact

Questions, corrections, or anything else about this page.